Analysis of Vaginal Microbicide Film Hydration Kinetics by Quantitative Imaging Refractometry
نویسندگان
چکیده
منابع مشابه
Analysis of Vaginal Microbicide Film Hydration Kinetics by Quantitative Imaging Refractometry
We have developed a quantitative imaging refractometry technique, based on holographic phase microscopy, as a tool for investigating microscopic structural changes in water-soluble polymeric materials. Here we apply the approach to analyze the structural degradation of vaginal topical microbicide films due to water uptake. We implemented transmission imaging of 1-mm diameter film samples loaded...
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A vaginal microbicide could slow the spread of HIV. To date, volunteers in placebo-controlled trials of candidate microbicides have been counseled to use condoms. This does not reduce the number of volunteers exposed to possible risk, but it shifts the allotment of risk from those conducting the trial to those women who may be least able to make autonomous decisions. Alternative ways of meeting...
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The purpose of this study was to assess adolescent women's preferences for specific microbicide characteristics including pregnancy prevention, timing of application, potential for side effects, and whether it targeted human immunodeficiency virus (HIV) or other sexually transmitted infections (STI). Potential differences in microbicide preferences by adolescent age group and behavioral pattern...
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BACKGROUND The development of safe topical microbicides that can preserve the integrity of cervicovaginal tract epithelial barrier is of great interest as this may minimize the potential for increased susceptibility to STI infections. High resolution imaging to assess epithelial integrity in a noninvasive manner could be a valuable tool for preclinical testing of candidate topical agents. MET...
متن کاملVaginal Microbicide Preferences Among Midwestern Urban
Purpose—The purpose of this study was to assess adolescent women’s preferences for specific microbicide characteristics including: pregnancy prevention, timing of application, potential for side effects, and whether it targeted Human Immunodeficiency Virus (HIV) or other sexually transmitted infections (STI). Potential differences in microbicide preferences by adolescent age group and behaviora...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0095005